By David Kaiza
Kampala, Nov 2003
The pinprick of the needle on the finger is more telling than the bite of a mosquito; quick and expected, it breaks the skin on the finger tip with a sharp jarring pain, unlike the quiet attack of the female anopheles; thepatient's body jerks in shock, the blood is drawn in a thin glass tube, or spread on a glass slide:
As a Ugandan studying the malaria control program in Brazil, this was not quite what I expected. But some twenty or so minutes later, the verdict was undeniably clear under the microscope. The ruptured red blood cell stained purple by the iodine drop and wedged firmly inside it, the classic magnified yellow image of the malaria parasite confirmed that I was infected.
The wedge was in only one cell so far. But in time, the other cells, still intact and round, would be invaded too. With more and more of them destroyed, the malaria parasites would thin down my blood into mere fluid - colourless plasma without much use. Because the red blood cells carry oxygen, this plasma would lose the capacity to transport that essential gas to the organs of the body needing them. In time, essential body organs could be damaged. With free reign, the parasites replicate, clinging on to the walls of the blood vessels while they mutate, clogging them up, in an act scientists refer to as sequestration. It disrupts the flow of blood, like a sewerage system with too much solid waste. A number of things begin to happen: My eyes would become pale and dull, bloodless because the blood, emptied of red blood cells, has lost colour. The kidneys, because they have more work filtering the blood clogged with unwanted haemoglobin waste, shut down from sheer stress. And the lungs, because they have got the largest, most intricate network of tiny blood vessels, which vessels have been clogged up by those clinging parasites, would fill with fluid as blood, trying to find an easier route, bursts the vessels. Like a river overflowing its banks, the blood floods the surrounding tissue with destructive consequences. Without oxygen and under attack from sequestered parasites, the brain shuts down. The kidneys could be damaged for good, the lungs ruined: Death.
3000 people, for whom effective treatment is unavailable to halt the parasites in their trucks, are said to end
up at the last point on a daily basis - 9 out of 10 of them in Africa. I was lucky that the first signs of malaria - unease and a flat taste in the mouth found me at the Institute for Tropical Medicine in Manaus, capital of the state of Amazonas in northern Brazil - a region of overactive climate where humidity is high, the vegetation dense and wet - very conducive breeding grounds for mosquitoes.
My malaria as the tests showed did not come from the Amazonas. I had carried it for weeks unknowing, in what doctors term "asymptomatic" malaria. It means that while a person is carrying malaria parasites, the condition does not progress to illness. It is an unquantifiable condition in many people in Africa, where a large number are immune to the disease and carry on normally. A change in climate, or diet or an increase in stress is said to lower that immunity and then the parasites, as in my case, jump to attack the body.
This is precisely what happened to me two days before I was due to arrive in Brazil. In Switzerland, unlike much of the world, medical facilitation is excellent. I did not have to line up in a hospital ward. I called a doctor from the hotel room, who arrived promptly at the appointed time. Back home in Uganda, where the doctor to patient ratio is 1:18,000, finding a doctor within the radius of ten kilometers would have been a task. Add to that the possibility that the requisite drugs might be unavailable even after a doctor has been found. There is the added possibility that the parasites will be resistant to the drug.
That was four days before Manaus. The malarone that was prescribed to me in Geneva and the 200 Swiss Francs I paid in consultation fee, plus the 67 Swiss Francs it later cost me to purchase the malarone came to nothing. No sooner had I taken the last three tablets of the malarone than I was sick again. I did not know it back in Switzerland, but in Brazil, the doctors told me that they had stopped prescribing malarone for along time because patients were still ill at the end of the treatment. The same was true of chloroquine, and as in Eastern Africa, of the alternative that governments jumped to after abandoning chloroquine; Sulphadoxine Pyremethamine, or SP or Fancidar as it is commonly known.
Having malaria brought me closer to my subject than is good for any objective study. But the irony was also fortuitous for it gave me first hand experience of how the Brazilian system worked. Hence for me as for 47 year old Lucimar Andrade da Silva, mother of a two week old daughter, and for her husband, Allyson Lima da Silva who went for treatment at the Institute for Tropical Medicine in Manaus, the system reacted rather fast: With my blood sample taken, my name was entered on the central malaria data system which the entire Brazilian government would read. I was given a further dose of mefloquine.
The system that treated me in Brazil goes back to 1999/2000, the time during which traditional approaches to fighting malaria were changed. It was part of a wider change in view, internationally, in which governments came to the realisation that health problems were much wider than availability of drugs and health facilities. Political will and backing was seen at the time as essential in solving health challenges in society. In this vein, former Brazilian president, Fernando Cardoso convened a meeting with the state governors of Brazil, at which commitments were made to combat malaria administratively, as medically.
Observers in Brazil say that this commitment has largely paid off. Within two years of setting up a system to combat the disease, the number of infections in the country had dropped down from 600,000 to 370,000.
HISTORY: From Eradication to Control
Malaria is the disease of the poor. The wealthier coastal metropolis of Sao Paulo and Rio de Janeiro, no longer have malaria except for imported cases. In stead, it is the dramatically poorer northern states particularly Amazonas that still report cases of malaria on a large scale. As incomes go up, so the chances of catching malaria go down. According to Dr. Walter Ferreira, director of the Instituto de Medicina Tropical at the University of Sao Paulo, industrialisation went to a large extent in ridding Southern Brazil of the menace.
"As a consequence of development, the ecology changed," he says. "We have no forest anymore. The vector found it hard to grow."
A century ago, malaria ravaged Brazil. The 1902 Pan American meeting which pointed out the dangers of malaria did not kick into action until the 1930s and 1940s when eradication measures were first taken on a wide scale in Brazil. Dichlorodiphenyltrichloroethane, DDT, was used widely as a spray. An interesting case of governmental action in eliminating the mosquito was in the north eastern states of Brazil. But it was not the Brazil government. In stead, what was a piece of the war effort of the USA government, proved a lasting gift to the poor of north eastern Brazil. It was World War II. The USA was using this part of Brazil as a hopping ground to send troops through West Africa to the war theatre in North Africa but the region was mosquito infested. The realisation that malaria was a danger to the war effort led to a wide scale spraying using an insecticide known as Green Paris. The troops stayed only briefly, but the impact is still felt today.
This period was the peak of the malaria epidemic, with up to 6 million cases reported. The intensity of the eradication drive did not relax and in 1960, a national eradication was adopted. Much of Brazil was left malaria free. These efforts were not applied in the Amazonas region, still too distant from the economically dynamic south.
Although Brazil is largely considered malaria free, scientists say that the level of support to research could make the claims questionable. The eradication, they say worked relatively well because sufficient funds were made available on time. Today, the complaint is that the more charismatic HIV/Aids is taking a greater priority. Scientists say there is danger that urban malaria could be growing unknown, because the diagnostic tools to test for the parasite, malariae are unavailable.
On the whole, Dr. Jarbas Barbosa, secretary for surveillance in the Ministry of Health, says that the eradication succeeded largely because up to the 1970s, scientists and public officials believed "they could do anything."
Dr. Walter Ferreira points out that the successes in the south led to relaxation and says that "the decrease was because we had a lot of money directed into control and now we don't have a lot of money."
The destruction of the ecosystem, which altered the breeding grounds of the rather sensitive female anopheles mosquito, are today largely unacceptable, for according to Dr. Ferreira, industry, apart from cutting down forests, also led to a systematic re-ordering of the landscape. The chemical compounds deposited into the air and the land destroyed the mosquito. These measures cannot today receive popular support anywhere in the world. Hence, the language on malaria has changed from eradication to control.
However, there are questions of income levels, which show that malaria is also an income-insensitive illness. Even in the northern city of Manaus, a burgeoning urban are right in the middle of the Amazon, malaria is no longer reported within the city, but in the peripheries where the poor are mostly to be found.
GOVERNANCE: Renewal and Commitment
Following the meeting in Brasilia between President Cardoso and state governors, the Brazilian government set targets, which are reviewed every two years. The first, in 1999, was to cut down the number of cases by 50 per cent by 2001. It achieved a reduction of 45 per cent. A further, more modest target was set to cut it down by another 30 per cent by 2003. The Statistics are pending.
The commitments presented a major shift in government policy against the disease: A lot is already known about the mosquito, the disease and the manner in which to fight it. But it often fails in many places because of loose governance. The decision to commit government hence shifted the disease from its elemental position as a bio-medical problem expected to be dealt with by slides and tablets, by focusing on the governance structure to ensure that slides and tablets are used correctly. It became a quantity to be watched through a structure fitted with backward and forward, review and evaluation linkages.
"It was the first time a program against a disease was led by a president," says Dr. Barbosa. "It was a challenge but it was an opportunity too because we were at the beginning of a decentralisation process so malaria was a good opportunity to build coordination."
The coordination set out a clear structure within the government of Brazil, a structure which drew up responsibilities right down to the grass roots, setting out what was expected of each level.
GOVERNANCE: Roles and Responsibilities
As an apex body, the Federal government coordinates the entire health system of the country. In the malaria control program, its task is to issue technical guidelines, which guidelines are often adapted to suit the locality in which they are to be implemented. This role involves disbursement of funds, purchases and supply of drugs and other forms of requisite logistics.
A step lower, the State government has to ensure that all spraying is done - in Ultra Low Volumes, with particles that stay in the air for days. The State has to meet a number of administrative requirements to quality for funds - all of which are geared towards ensuring that the State has the capacity to not only receive the funds, but to carry out the role for which the money is intended. It must have in place; infrastructure, personnel, a program to use the funds, a local health council and a specific bank account.
Once these basic requirements are satisfied, the amount of money disbursed will be tied to goals. The number of homes to be sprayed is taken into account together with the number of people treated and the number of slides taken within the period of the last fund release. The annual budget for malaria is $30 million or R$100 million.
At the Municipal level, control is the major task. The municipalities run posts in the risk areas, where a task as specific as taking tallies of mosquitoes is done. The posts also act as coordination centres to educate and inform the public about safety measures and the breeding habits of the mosquito.
In this vertical structure, a system of backward and forward linkage creates, and focuses vigilance on the progress of the control program. The thoroughness of the program is such that the details about every patient from age, address, diagnosis and treatment, are instantly available to all officials within the entire structure, from the medical personnel taking the blood sample at the Manaus hospital, to the Health Minister in Brasilia: All cases of malaria are entered into a database available on the Internet, by the medical personnel taking diagnosis at health centres in the endemic areas.
The instantaneous availability of information therefore creates a system that is easy to monitor and evaluate. But decentralisation created flexibility - the amount of time that it took between observation and turn-around in decision making was shortened. Before that, response to the illness itself was much slower. Brazil is a large country, which a centralised system could not effectively cover.
SOCIETY AND SCIENCE: Causes and the Search for solutions
Dr. Pedro Tauil, Assistant Professor in the Faculty of Medicine, University of Brasilia and health advisor to the Federal Senate says that reducing the time between the first appearance of symptoms, diagnosis and treatment was necessary as a basic control measure. Speed is essential: It takes only a short while for the parasites to reproduce within the human body, meaning that a window period is available in every case to stop mosquitoes from transmitting malaria from one person to another. Says Tauil: "If you treated the person on time, you reduce the risk of infecting another person."
For this to be possible, diagnostic tools had to be readily available. As part of the renewed campaign, the number of diagnostic posts was increased from 3,000 to 30,000.
Brazil is a gigantic country which when stretched out would cover the landmass of Africa from South Africa to Uganda. But it is a country with large inequalities between the rich and the poor. No where is this inequality more acute than in land distribution. The landless see the Amazonas as a region with plenty of land, and this is where human settlement is expanding:
On most afternoons, the air over the Amazon is thickly humid and hot. The rows of houses lying unprotected under the sweltering heat of the tropical sun; the construction basic and done hurriedly, is Nova Cidade. It is the new city which is expanding the city limits of Manaus. This is a raw and recent invasion of the great forest by man. The long and wide gullies, the raw, rotting smell of destroyed plants, uncovered forest undergrowth mixing in with the smell of construction material and the intoxicating smell of tar heated by the sun are tell tale signs that this place is new. Uncovered after thousands of years, the top soil lies loose on the unsealed roads and on the six by six or so feet of courtyards in front of each house. The sun dries these up and when it rains, the beige colour sticks to everything. The road might be bitumised. But the tar is hurriedly done, the foundation of the road is thin and unstable and under the high temperatures, the surface of the road melts, flows, is lumpy and potholed immediately. Vehicles heave and tug about like boats on rough water as they drive along. When it rains, the water gathers in pools or in anything that is upturned - a pothole, a tin, eggshell or polythene bag. Life is hard here and with small income, appearances of a nice neighbourhood are a distant luxury. These settlements are based on the improved slums in South Africa, and like in South Africa, the inhabitants are acutely aware of their poverty, their depravity in one of the world's largest economies. Here, the connection between poverty and malaria are dramatised:
"The malaria in the Americas is different from that in Africa," says Dr. Carlos Protaes Loiola Catao, Manager of the National Malaria Program, Fundacao Nacional de Saude. "Our malaria is largely from movement to endemic areas with poor infrastructure and poor health sector."
The da Silvas are caught up in the same impermanence. They at one time hunted in the forests for a living. Then they fished. They upgraded from that to aquaculture - right on the banks of the Rio Negro, one of the two principal rivers of South America that joins up with the Amazon River 12 kilometers on the outskirts of Manaus. It is a spectacular site known in Portuguese as Encontras dos Aguas, the black of the Rio Negro meeting the brown of the Amazon. But those who make a life there also risk losing it to mosquitoes. Fishing stands along side punning for gold as high risk behaviour in Brazil. Both involve working in mosquito infested waters. Gold punning diverts water from the flowing rivers and creates stagnant pools. Aquaculture involves building ponds which breed both mosquito and fish.
Those who report to the hospital fit the same bill as da Silva. "They have no land to build a house and have to invade the forest," says Dr. Luiz Ferreira, pathologist at the Institute of Tropical Medicine in Manaus. "When they begin to cut the trees, the pools of water become a lake. When it becomes a lake, it's a good place for the mosquito to put their eggs."
Combate A Malaria E Dengue, Base De Operacoes is at the very edge of the Amazon, as it is at the very edge of the malaria program itself. Some hundreds of meters away, starts the density of wood and creeper that is the great forest. Situated in Nova Cidade, a few kilometers outside Manaus, it is one of the outposts maintaining a daily vigilance against the mosquito. All around the post are the rows of new houses built where there used to be forest.
Anastacia Venaucio is one of the young men and women in this Manaus outpost. Her bright yellow T-Shirt, like that of her colleagues, reads, "Forca Total Contra A Malaria". The small red makeshift house they operate in is the outpost that monitors the malaria and dengue risk in the expanding settlement of Nova Cidade. It is here that the national malaria control program makes contact with the targeted population. It is here that it must make its impact felt to be successful.
"We visit houses and ask for permission to go inside to search for mosquitoes," says Venaucio. "We look around the house for possible breeding sites. It maybe very small like a bottle or eggshells, plastic bags, flowerpots. There are some plants which have breeding spots."
Teams are dispatched from the post to the community to map out the areas according to the density of mosquitoes. In the evenings, the girls use their own bodies as bait to trap mosquitoes. They are then tallied. The information is used to draw a map, which then indicates the spots that need the most attention, a variant of what is referred to as stratification.
When they visit the people on the edges of the forest and rivers, they take them through the life cycles of the mosquitoes, explaining that the "warms" wriggling in stagnant pools of water will graduate into mosquitoes.
"We show them the evolution of the mosquito because the people don't always associate the larvae with the mosquito," says Venaucio.
Once the messages have been given out, an evaluation is carried out, to find out if the prevention messages have reached the target. Venaucio says that following each intensive campaign period, there are fewer larvae around homes. The number of people falling sick too goes down. "We feel victorious," she says. "In such a time we have solved so much."
Nova Cidade started its life as a rough settlement, which in the absence of government, was growing without plan - a sure risk factor for any infectious disease to gain grip. With the coming into force of the new malaria drive, government has now taken over. The new houses are built to offer protection against mosquitoes; fitting windows with netting and making sure water drainage is well managed. Here as elsewhere, the risk of malaria and dengue fever are considered before a major project is unrolled, as part of what Dr. Barbosa refers to as "malaria safe development."
In the states that have brought malaria under control, care is taken to avoid infection, for as Dr. Silvia Santi, researcher at the Superindencia de Controle de Endemias (SUCEN) in Sao Paulo points out, mosquitoes do not naturally have malaria parasites, but will act as the vector when one individual carrying the parasites in a population is bitten by the female anopheles, which then goes to bite a healthy person and introduces the parasites into their blood system. An example of where this happened is Madagascar, thousands of kilometers away on the other side of the Atlantic Ocean and the African continent. The Island country had at one time managed to eradicate malaria. Although they had mosquitoes, the bites of the female anopheles were harmless. Later, immigrants carrying the parasites reintroduced the disease into the island. The mosquitoes were once more biting into infected bloodstreams.
There is realisation therefore that even after successful treatment, a constant vigilance has to be mounted. A concept referred to as stratification was once tried out in a pilot project, although it has not been implemented en masse. Under this concept, areas are zoned out according to the degree of risk. Once a successful control measure has been carried out in zone A, all the people moving in from zone B or C, must be tested first for the parasites. If positive, they have to receive treatment as a requisite measure, more like most countries require a yellow fever certificate alongside a passport before admission. This showed that malaria could be effectively contained. But it also tended to work with smaller geographical areas.
The following categorisation is considered in drawing up the strata of endemicity: Where more than 50 people out of 1000 have malaria, the region is marked as high risk. 10 to 49 out of 1000 is medium risk and 0 to 10 is low risk.
Aspects of stratification - useful for concentrating resources were they are most needed - are actively pursued in Sera Pelada, a predominantly agricultural are in northern Brazil. "All the people who go to the area must have negative blood and if they are positive, they must receive treatment," says Dr. Santi.
So is it possible to arrive at a situation where the disease has been completely eliminated in a country so that mosquito bites are reduced to a harmless irritant?
"If everybody is treated at the same time, you can eliminate the disease," says the Director of the University Hospital in Sao Paulo, Dr. Marcus Boulos. "But this depends on other variables."
Variables such as the habits of the mosquito, the strength of a particular strain of parasite, the size of the area under control and the habits of the people. The mosquitoes that spread malaria in Brazil bite between 5 and 7 o'clock in the evening and then from 5 to 7 in the morning. In Africa, the female anopheles feeds from 10 in the evening to 4 in the morning. In Brazil, sleeping under the net is not necessary. Risky behaviours that lay people open to the mosquito at these hours have to be identified. In this way, Forca Total Contra A Malaria therefore prints out leaflets that tell the people to:
* Avoid taking baths past five o'clock in the evening,
* Wear trousers and long sleeved shirts,
* Use repellants,
* Protect windows with netting, and
* Not to wash clothes near streams.
To keep a tight lid on the disease, it is also necessary to keep constant watch on the use of drugs to ensure compliance with treatment regiments. Drugs must be taken at the right time in the right dosage: "Sometimes, when people are not well informed, they take drugs and then stop the dosage when they feel a little better.
They keep them for the next time they fall ill," says Dr. Santi.
Sometimes, the type of houses that people construct and live in will determine whether mosquitoes invade or whether the control measure will be effective: Says Dr. Tauil; "In an urban area, you may apply environmental methods. You reduce the breeding sites. You clean the drainage. When the houses have walls you may apply insecticides. But in some areas, houses are made of poles and canvas."
It is in the pole and canvas environment that Lucimar da Silva made her living. But as a result of the education campaign from Forca Total A Malaria, she is choosing a different location to make her home now - Boa Vista, less risky compared to Igarape do Ehita.
Other variables will also depend on whether a population makes the link between planned settlement, the larvae, the mosquito and lost productivity. Malaria must be treated as a strange and dangerous phenomenon to be fought adequately.
"In Sera Pelada," explains Dr. Boulos, "economic interests were linked to malaria. Farmers realised the connection between illness and decreased productivity."
As a consequence, the pressure to increase surveillance mounted, armed with this solid evidence. Today, lay people are trained to man some of the diagnosis posts. Miners and farm workers are to be found mounted atop microscopes. As Dr. Catao explains, it would be a good thing to have technicians everywhere where there is a danger, but there are not that many to go around. That has not stopped the program either.
With these ideas and responses, the drive started in 1999 showed some results. At the start, the number of states in the Amazonas classified as high risk were 39; medium risk, 12 and low risk, 11. By 2001, high risk states were down to 10, medium risk gone to 27 and low risk, 25. This year, he expects the number of states coloured bright red - to classify high risk - to have fallen even further, but the statistics are not yet ready.
Overall, since 1999, the number of high-risk municipalities in Brazil has fallen from 200 to 98.
The drive to avail treatment free of charge was driven by the pragmatism that malaria was a disease of the poor, affecting those, who like da Silva, scavenge for a living at the margins of society. "The private sector in Brazil don't have interest in the treatment of malaria because the remuneration is low. Malaria is not a disease for the middle class but for the poor who don't have money. But the public sector has a duty to treat these people," explains Dr. Catao.
FRONTIERS: Unanswered questions
Under the decentralization process, the Federal government cannot hire people on a permanent basis, so it has to keep recruiting and retraining people to work on the malaria and dengue program. It is a wasteful process that has seen the Amazonas region employ 35,000 people so far.
Although Dr. Barbosa says that elimination of malaria is not feasible with the available information, researchers say that there is less money now being put into research. There is fear that with elimination in the southern states, there is no more immunity amongst the population, with the fear that urban malaria could easily jump in. already, one case of malaria infection, malarae, which jumped from monkey to man, was found, but only after the patient died.
The Tropical Institute says that it needs more resources to research and develop new diagnostic tools but that they receive hardly any support. Dr. Walter Ferreira and Dr. Marcus Boulos in Sao Paulo, and Dr. Franklin Simoes in Manaus, say that resources must be put into research to ensure that Brazil does not see a resurgence after this current drive runs out of steam.
"We are a pearl in the middle of the jungle who would like to shine. Most of the budget for the WHO goes to Africa but we would also like some money here. [O]